- --------                             U.S. SECURITIES AND EXCHANGE COMMISSION                        --------------------------------
 FORM 4                                      Washington, D.C. 20549                                           OMB APPROVAL          
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[_] Check this box if no           STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP                     OMB Number:            3235-0287
    longer subject to                                                                               Expires:      September 30, 1998
    Section 16.  Form 4    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,  Estimated average burden        
    or Form 5 obligations   Section 17(a) of the Public Utility Holding Company Act of 1935         hours per response.......... 0.5
    may continue.  See         or Section 30(f) of the Investment Company Act of 1940               --------------------------------
    Instruction 1(b). 

(Print or Type Responses)
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1.  Name and Address of           2.  Issuer Name and Ticker or                     6.  Relationship of Reporting Person to Issuer  
    Reporting Person*                 Trading Symbol                                             (Check all applicable) 
                                                                                            
Lopez, M.D.  George      A.       ICU Medical, Inc. (ICUI)                               [X] Director        [ ]  10% Owner
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(Last)      (First)    (Middle)   3.  IRS or Social         4. Statement for              X  Officer (give   ____ Other (specify
                                      Security Number of       Month/Year               ----         title               below)
                                      Reporting Person         February 1999                         below)
951 Calle Amanecer                    (Voluntary)                                            President, Chief Executive Officer
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        (Street)                                            5.  If Amendment,                    and Chairman of the Board       
                                                                Date of Original                 -------------------------
San Clemente, CA 92673                                          (Month/Year)        7.  Individual or Joint/Group Filing (Check
                                                                                        Applicable Line)
                                                                                      X   Form filed by One Reporting Person 
                                                                                     ----    
                                                                                     ____ Form filed by More than One Reporting
                                                                                          Person
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(City)        (State)    (Zip)          Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 
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1.  Title of Security             2. Trans-  3. Trans-      4. Securities Acquired (A)  5.  Amount of    6. Owner-    7.  Nature of
    (Instr. 3)                       action     action         or Disposed of (D)           Securities      ship          Indirect
                                     Date       Code           (Instr. 3, 4 and 5)          Beneficially    Form:         Beneficial
                                                (Instr. 8)                                  Owned at        Direct        Ownership
                                   (Month/   -------------------------------------------    End of Month    (D) or In-    (Instr. 4)
                                     Day/                              (A) or               (Instr. 3       direct (I)          
                                    Year)    Code     V     Amount     (D)       Price      and 4)          (Instr. 4)
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Common Stock                        2/24/99  J(1)          791,742     A         21.00(1)   791,742(2)          I           (1)    
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(1)  George A. Lopez, M.D. and Diana K. Lopez, M.D., his wife, are the general partners of the George A. Lopez, M.D. Second Family
     Limited Partnership (the "Partnership") and hold a one-percent general partnership interest in the Partnership. As general
     partners, they share power to vote and power to dispose of the 791,739 shares owned by the Partnership and may deemed to be
     beneficial owners of such shares. The Partnership acquired the shares on 2/24/99 from Trusts for the benefit of the Lopez'
     children, the Christopher George Lopez Children's Trust and the Nicholas George Lopez Children's Trust, which own a 99% limited
     partnership interest in the Partnership. The Drs. Lopez are not trustees of and have no interest in their children's Trusts.
     Except to the extent of their undivided one percent general partnership interest in the assets of the Partnership, the Drs.
     Lopez disclaim any beneficial ownership of the shares owned by the Partnership.
(2)  Excludes 250,000 Common Shares are hold in Lopez Trust CRT #1.  Also excludes 12,006 shares held by Dr. Lopez' wife.  Dr. Lopez
     disclaims any beneficial interest in the shares held by the Trust and by his wife.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                  (Over) 
 * If the form is filed by more than one reporting person, see Instruction 4(b)(v).                                 SEC 1474 (7-96)
FORM 4 (continued) Table II - Derivative Securities Acquired, Disposed of, of Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Derivative 2. Cover- 3. Trans- 4. Trans- 5. Number of 6. Date Exer- 7. Title and Amount of Security (Instr. 3) sion or action action Derivative cisable and Underlying Securities Exercise Date Code Securities Expiration (Instr. 3 and 4) Price of (Month/ (Instr. 8) Acquired (A) Date (Month/ Deriv- Day/ or Disposed Day/Year) ative Year) of (D) (Instr. ---------------------------------------- Security 3, 4, and 5) Date Expira- Amount or -------------------------------- Exer- tion Title Number of Code V (A) (D) cisable Date Shares - ------------------------------------------------------------------------------------------------------------------------------------ Options to Acquire 11.25 1/30/99 10/13/05 Common Stock 100,000 - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 8.19 2/12/99 10/3/07 Common Stock 298,000 - ------------------------------------------------------------------------------------------------------------------------------------ 8.31 1/30/99 1/31/08 Common Stock 280,000 - ------------------------------------------------------------------------------------------------------------------------------------ 15.37 1/30/99 6/26/07 Common Stock 380,000 - ------------------------------------------------------------------------------------------------------------------------------------ 12.25 * 1/2/09 Common Stock 650,000 - ------------------------------------------------------------------------------------------------------------------------------------ 12.25 1/30/99 1/2/09 Common Stock 32,655 - ------------------------------------------------------------------------------------------------------------------------------------ 12.25 * 1/2/09 Common Stock 67,345 - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Derivative 8. Price 9. Number 10. Ownership 11. Nature of Security (Instr. 3) of of Form of Indirect Deriv- Deriv- Derivative Beneficial ative ative Security: Ownership Security Securities Direct (D) (Instr. 4) (Instr. 5) Beneficially or Indirect Owned at (I) End of Month (Instr. 4) (Instr. 4) - ------------------------------------------------------------------------------------------------------------------------------------ N/A 100,000 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 298,000 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 280,000 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 380,000 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 650,000 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 32,655 D - ------------------------------------------------------------------------------------------------------------------------------------ N/A 67,345 D - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ * Options exercisable on 1/2/08 or earlier upon achievement of certain performance objectives, as specified in the option agreement.
Explanation of Responses: ** Intentional misstatements or /s/ George A. Lopez M.D. 3/9/1999 omissions of facts constitute -------------------------- -------------- Federal Criminal Violations. **Signature of Date See 18 U.S.C. 1001 and Reporting Person 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number. Page 2 SEC 1474 (7-96)